https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 DNA damage and repair in the female germline: contributions to ART https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37385 Wed 28 Oct 2020 18:12:02 AEDT ]]> Development of a model for studying the developmental consequences of oxidative sperm DNA damage by targeting redox-cycling naphthoquinones to the Sertoli cell population https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52590 Wed 28 Feb 2024 15:32:45 AEDT ]]> Mechanisms of tethering and cargo transfer during epididymosome-sperm interactions https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45249 Wed 26 Oct 2022 19:43:42 AEDT ]]> Mechanistic insight into the regulation of lipoxygenase-driven lipid peroxidation events in human spermatozoa and their impact on male fertility https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45204 Wed 26 Oct 2022 15:29:09 AEDT ]]> Assisted breeding technology in the saltwater crocodile Crocodylus porosus: a review and look to the future https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43523 Wed 21 Sep 2022 11:25:36 AEST ]]> Molecular changes induced by oxidative stress that impair human sperm motility https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40952 Wed 20 Jul 2022 15:22:13 AEST ]]> A novel role for milk fat globule-EGF factor 8 protein (MFGE8) in the mediation of mouse sperm–extracellular vesicle interactions https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49349 Wed 17 Apr 2024 10:02:24 AEST ]]> Dynamic Landscape of Extracellular Vesicle-Associated Proteins Is Related to Treatment Response of Patients with Metastatic Breast Cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40283 Wed 13 Mar 2024 08:47:04 AEDT ]]> More than a simple lock and key mechanism: unraveling the intricacies of sperm-oocyte interactions https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15653 Wed 11 Apr 2018 17:40:40 AEST ]]> Evidence for the involvement of PECAM-1 in a receptor mediated signal-transduction pathway regulating capacitation-associated tyrosine phosphorylation in human spermatozoa https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1527 Wed 11 Apr 2018 16:54:55 AEST ]]> Molecular and functional characterization of the rabbit epididymal secretory protein 52, REP52 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4505 Wed 11 Apr 2018 16:03:28 AEST ]]> Mouse spermatocytes express CYP2E1 and respond to acrylamide exposure https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16821 Wed 11 Apr 2018 15:45:52 AEST ]]> A unique combination of male germ cell mirnas coordinates gonocyte differentiation https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15133 Wed 11 Apr 2018 14:23:25 AEST ]]> Assessment of microRNA expression in mouse epididymal epithelial cells and spermatozoa by next generation sequencing https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26301 Wed 11 Apr 2018 14:11:17 AEST ]]> Next generation sequencing analysis reveals segmental patterns of microRNA expression in mouse epididymal epithelial cells https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26480 Wed 11 Apr 2018 13:21:00 AEST ]]> Chronic acrylamide exposure in male mice results in elevated DNA damage in the germline and heritable induction of CYP2E1 in the testes https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27712 Wed 11 Apr 2018 12:01:24 AEST ]]> Dynamin 2 is essential for mammalian spermatogenesis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27739 Wed 11 Apr 2018 11:56:44 AEST ]]> Characterisation of mouse epididymosomes reveals a complex profile of microRNAs and a potential mechanism for modification of the sperm epigenome https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30207 350 microRNAs (miRNAs), a developmentally important sRNA class, the majority (~60%) of which are also represented by the miRNA signature of spermatozoa. This includes >50 miRNAs that were found exclusively in epididymal sperm and epididymosomes, but not in the surrounding soma. We also documented substantial changes in the epididymosome miRNA cargo, including significant fold changes in almost half of the miRNAs along the length of the epididymis. Finally, we provide the first direct evidence for the transfer of several prominent miRNA species between mouse epididymosomes and spermatozoa to afford novel insight into a mechanism of intercellular communication by which the sRNA payload of sperm can be selectively modified during their post-testicular maturation.]]> Wed 11 Apr 2018 11:13:04 AEST ]]> Are sperm capacitation and apoptosis the opposite ends of a continuum driven by oxidative stress? https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27621 Wed 11 Apr 2018 10:16:30 AEST ]]> Identification of the molecular chaperone, heat shock protein 1 (chaperonin 10), in the reproductive tract and in capacitating spermatozoa in the male mouse https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4506 Wed 11 Apr 2018 10:11:11 AEST ]]> Electrophilic aldehyde products of lipid peroxidation selectively adduct to heat shock protein 90 and arylsulfatase A in stallion spermatozoa https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34663 Wed 10 Apr 2019 13:35:43 AEST ]]> Autophagy in female fertility: a role in oxidative stress and aging https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38419 Wed 08 Sep 2021 16:10:39 AEST ]]> Finding needles in haystacks: the use of quantitative proteomics for the early detection of colorectal cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46915 Wed 07 Dec 2022 09:37:40 AEDT ]]> Biocompatible Nanomaterials as an Emerging Technology in Reproductive Health; a Focus on the Male https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50158 Wed 05 Jul 2023 15:35:31 AEST ]]> Dynamin 2-dependent endocytosis is essential for mouse oocyte development and fertility https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45607 Wed 02 Nov 2022 14:14:14 AEDT ]]> Development of peptides for targeting cell ablation agents concurrently to the Sertoli and Leydig cell populations of the testes: An approach to non-surgical sterilization https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55214 Wed 01 May 2024 10:39:22 AEST ]]> Male Infertility: Shining a Light on Lipids and Lipid-Modulating Enzymes in the Male Germline https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49743 Tue 30 May 2023 15:29:49 AEST ]]> Investigation into the presence and functional significance of proinsulin C-peptide in the female germline https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47613 Tue 24 Jan 2023 11:43:18 AEDT ]]> Global profiling of the proteomic changes associated with the post-testicular maturation of mouse spermatozoa https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51128 6,000 proteins, encompassing the selective loss and gain of several hundred proteins. Further, we demonstrate epididymal-driven activation of RHOA-mediated signaling pathways is an important component of sperm maturation. These data contribute molecular insights into the complexity of proteomic changes associated with epididymal sperm maturation.]]> Tue 22 Aug 2023 15:52:22 AEST ]]> Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice. https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40723 Tue 21 Mar 2023 18:42:13 AEDT ]]> Oxidative Stress Dysregulates Protein Homeostasis within the Male Germ Line https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43152 Tue 13 Sep 2022 15:28:32 AEST ]]> Non-surgical sterilisation methods may offer a sustainable solution to feral horse (Equus caballus) overpopulation https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33177 Tue 11 Sep 2018 12:15:39 AEST ]]> A Kinase Anchor Protein 4 is vulnerable to oxidative adduction in male germ cells https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36571 Tue 09 Jun 2020 11:40:42 AEST ]]> Molecular insights into the divergence and diversity of post-testicular maturation strategies https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40953 Tue 07 Nov 2023 09:51:49 AEDT ]]> Heat shock protein A2 (HSPA2): regulatory roles in germ cell development and sperm function https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33498 Tue 06 Nov 2018 11:19:37 AEDT ]]> Analysis of the small non-protein-coding RNA profile of mouse spermatozoa reveals specific enrichment of piRNAs within mature spermatozoa https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34061 Tue 05 Feb 2019 14:14:54 AEDT ]]> Characteristics of the epididymal luminal environment responsible for sperm maturation and storage https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34727 Tue 03 Sep 2019 17:57:47 AEST ]]> Improved methods of DNA extraction from human spermatozoa that mitigate experimentally-induced oxidative DNA damage https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34948 Tue 03 Sep 2019 17:57:02 AEST ]]> Characteristics of the epididymal luminal environment responsible for sperm maturation and storage https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34015 Tue 03 Sep 2019 17:54:59 AEST ]]> Developmental expression of the dynamin family of mechanoenzymes in the mouse epididymis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34016 Thu 30 May 2019 15:47:52 AEST ]]> Characterization of a novel role for the dynamin mechanoenzymes in the regulation of human sperm acrosomal exocytosis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34014 Thu 30 May 2019 15:41:20 AEST ]]> Analysis of epididymal protein synthesis and secretion https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34868 Thu 30 May 2019 15:31:33 AEST ]]> A scRNA-seq Approach to Identifying Changes in Spermatogonial Stem Cell Gene Expression Following in vitro Culture https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44824 Thu 27 Oct 2022 12:44:28 AEDT ]]> A regulatory role for CHD4 in maintenance of the spermatogonial stem cell pool https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45372 Chd4 expression significantly impairs SSC regenerative capacity, causing a ∼50% reduction in colonization of recipient testes. An scRNA-seq comparison revealed reduced expression of “self-renewal” genes following Chd4 knockdown, along with increased expression of signature progenitor genes. Co-immunoprecipitation analyses demonstrated that CHD4 regulates gene expression in spermatogonia not only through its traditional association with the remodeling complex NuRD, but also via interaction with the GDNF-responsive transcription factor SALL4. Cumulatively, the results of this study depict a previously unappreciated role for CHD4 in controlling fate decisions in the spermatogonial pool.]]> Thu 27 Oct 2022 12:14:10 AEDT ]]> Large expert-curated database for benchmarking document similarity detection in biomedical literature search https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44994 Thu 27 Oct 2022 09:09:41 AEDT ]]> A novel approach to nonsurgical sterilization; application of menadione-modified gonocyte-targeting M13 bacteriophage for germ cell ablation in utero https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38313 Thu 26 Aug 2021 13:31:44 AEST ]]> Development of a novel electrophoretic system for the isolation of human spermatozoa https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27 Thu 25 Jul 2013 09:10:14 AEST ]]> A novel approach to non-surgical sterilization https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37398 Thu 16 Nov 2023 12:24:42 AEDT ]]> Oxidative damage in naturally aged mouse oocytes is exacerbated by dysregulation of proteasomal activity https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43344 Thu 15 Sep 2022 15:19:01 AEST ]]> Mouse quiescin sulfhydryl oxidases exhibit distinct epididymal luminal distribution with segment-specific sperm surface associations https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43294 Thu 15 Sep 2022 12:51:41 AEST ]]> Modification of crocodile spermatozoa refutes the tenet that post-testicular sperm maturation is restricted to mammals https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35956 Thu 14 May 2020 15:11:42 AEST ]]> Elucidation of the protein composition of mouse seminal vesicle fluid https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47101 Thu 06 Jul 2023 14:06:28 AEST ]]> Inhibition of arachidonate 15-lipoxygenase prevents 4-hydroxynonenal-induced protein damage in male germ cells https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32117 Thu 03 May 2018 12:04:54 AEST ]]> Molecular mechanisms responsible for increased vulnerability of the ageing oocyte to oxidative damage https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30490 Thu 03 Feb 2022 12:19:24 AEDT ]]> New proteins identified in epididymal fluid from the platypus (Ornithorhynchus anatinus) https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7848 Sat 24 Mar 2018 08:42:26 AEDT ]]> Composition and significance of detergent resistant membranes in mouse spermatozoa https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7044 Sat 24 Mar 2018 08:37:51 AEDT ]]> DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2′-deoxyguanosine, a marker of oxidative stress https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:8206 Sat 24 Mar 2018 08:36:17 AEDT ]]> Adding insult to injury: effects of xenobiotic-induced preantral ovotoxicity on ovarian development and oocyte fusibility https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9651 Sat 24 Mar 2018 08:35:26 AEDT ]]> Localization and significance of molecular chaperones, heat shock protein 1, and tumor rejection antigen gp96 in the male reproductive tract and during capacitation and acrosome reaction https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1595 Sat 24 Mar 2018 08:30:41 AEDT ]]> New insights into sperm physiology and pathology https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11318 Sat 24 Mar 2018 08:12:33 AEDT ]]> Glioma pathogenesis-related 1-Like 1 is testis enriched, dynamically modified, and redistributed during male germ cell maturation and has a potential role in sperm-oocyte binding https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11115 Sat 24 Mar 2018 08:12:26 AEDT ]]> Elucidation of the signaling pathways that underpin capacitation-associated surface phosphotyrosine expression in mouse spermatozoa https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10106 Sat 24 Mar 2018 08:07:16 AEDT ]]> Monotremes provide a key to understanding the evolutionary significance of epididymal sperm maturation https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17414 Sat 24 Mar 2018 08:01:39 AEDT ]]> Capacitation in the presence of methyl-β-cyclodextrin results in enhanced zona pellucida-binding ability of stallion spermatozoa https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18685 Sat 24 Mar 2018 08:01:06 AEDT ]]> Melatonin prevents postovulatory oocyte aging in the mouse and extends the window for optimal fertilization in vitro https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20252 Sat 24 Mar 2018 07:59:55 AEDT ]]> Involvement of multimeric protein complexes in mediating the capacitation-dependent binding of human spermatozoa to homologous zonae pellucidae https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17664 Sat 24 Mar 2018 07:57:48 AEDT ]]> Investigation of the mechanisms by which the molecular chaperone HSPA2 regulates the expression of sperm surface receptors involved in human spermoocyte recognition https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20323 Sat 24 Mar 2018 07:55:12 AEDT ]]> Genome analysis of the platypus reveals unique signatures of evolution https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5001 Sat 24 Mar 2018 07:44:13 AEDT ]]> Investigation of the role of SRC in capacitation-associated tyrosine phosphorylation of human spermatozoa https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5003 Sat 24 Mar 2018 07:44:13 AEDT ]]> Localization and significance of molecular chaperones, heat shock protein 1, and tumor rejection antigen gp96 in the male reproductive tract and during capacitation and acrosome reaction https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:59 Sat 24 Mar 2018 07:42:05 AEDT ]]> Biochemical alterations in the oocyte in support of early embryonic development https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29633 2+2+ release and the suite of molecular modifications that sweep through the oocyte to ensure the successful union of the parental germlines and ensure embryogenic fidelity.]]> Sat 24 Mar 2018 07:41:53 AEDT ]]> Identification of a key role for permeability glycoprotein in enhancing the cellular defense mechanisms of fertilized oocytes https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27766 Sat 24 Mar 2018 07:40:49 AEDT ]]> Formation and dissociation of sperm bundles in monotremes https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27768 Sat 24 Mar 2018 07:40:48 AEDT ]]> Glycogen synthase kinase 3 regulates acrosomal exocytosis in mouse spermatozoa via dynamin phosphorylation https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27976 50 = 6.7 nM) led to a significant reduction in dynamin phosphorylation (10.3% vs. 27.3%; P < 0.001), acrosomal exocytosis (9.7% vs. 25.7%; P < 0.01), and in vitro fertilization (53% vs. 100%; P < 0.01). GSK3 was shown to be present in developing germ cells where it colocalized with dynamin in the peri-acrosomal domain. However, additional GSK3 was acquired by maturing mouse spermatozoa within the male reproductive tract, via a novel mechanism involving direct interaction of sperm heads with extracellular structures known as epididymal dense bodies. These data reveal a novel mode for the cellular acquisition of a protein kinase and identify a key role for GSK3 in the regulation of sperm maturation and acrosomal exocytosis.—Reid, A. T., Anderson, A. L., Roman, S. D., McLaughlin, E. A., McCluskey, A., Robinson, P. J., Aitken, R. J., Nixon, B. Glycogen synthase kinase 3 regulates acrosomal exocytosis in mouse spermatozoa via dynamin phosphorylation.]]> Sat 24 Mar 2018 07:38:43 AEDT ]]> Novel characterization of the HSPA2-stabilizing protein BAG6 in human spermatozoa https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27535 Sat 24 Mar 2018 07:28:58 AEDT ]]> Chronic acrylamide exposure in male mice induces DNA damage to spermatozoa; potential for amelioration by resveratrol https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27718 via the enzyme, cytochrome P450, family 2, subfamily E, polypeptide 1 (CYP2E1). Acrylamide was administered to male CD1 mice for three or sixmonths at a dose of 0.18 mg/kg bodyweight/day. DNA damage was detected in germ cells and maturespermatozoa of exposed mice without compromising their overall fertility. The use of resveratrol, anantioxidant and known CYP2E1 inhibitor, was found to ameliorate the DNA damage in both germ cells andspermatozoa. However, extended resveratrol treatment (six months, 10.0 mg/kg bw/week) resulted inpremature activation of these cells. Thus the DNA damage found in spermatozoa after chronic acrylamideadministration can be alleviated but an alternative CYP2E1 inhibitor may be required.]]> Sat 24 Mar 2018 07:24:39 AEDT ]]> A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitation https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26537 95% of sperm. Anapparent molecular rearrangement in the complex occurs, bringing PRKACA and TCP11 into proximity. Taken together, these results suggest a role for the novel complex of SPIF, PRKACA, and TCP11 during spermcapacitation, fertilization, and embryogenesis.]]> Sat 24 Mar 2018 07:23:27 AEDT ]]> Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22263 in vitro induction of acrosomal exocytosis by progesterone, but not by the calcium ionophore A23187, and elicited a concomitant reduction of in vitro fertilization. In vivo treatment with these inhibitors also resulted in spermatozoa displaying reduced acrosome reaction potential. Dynamin 1 and 2 phosphorylation increased on progesterone treatment, and this was also selectively blocked by dynasore. On the basis of our collective data, we propose that dynamin could regulate specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa.]]> Sat 24 Mar 2018 07:17:38 AEDT ]]> Chronic exposure to acrylamide induces DNA damage in male germ cells of mice https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25108 Sat 24 Mar 2018 07:17:15 AEDT ]]> Heat shock protein member A2 forms a stable complex with angiotensin convertingenzymeand protein disulfide isomerase A6 in human spermatozoa https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24127 Sat 24 Mar 2018 07:16:32 AEDT ]]> OXIDATIVE STRESS AND REPRODUCTIVE FUNCTION: Oxidative stress and in vitro ageing of the post-ovulatory oocyte: an update on recent advances in the field https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51259 Mon 28 Aug 2023 13:50:03 AEST ]]> Assessment of the impact of direct in vitro PFAS treatment on mouse spermatozoa. https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54975 Mon 25 Mar 2024 15:21:41 AEDT ]]> Double strand break DNA repair occurs via non-homologous end-joining in mouse MII oocytes https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32871 in vitro fertilisation, though displayed reduced developmental competence beyond the 2-cell stage (P=0.02). To account for these findings, we analysed the efficacy of DSB resolution, revealing a significant reduction in DSB lesions 4 h post-ETP treatment. Notably, this response was completely abrogated by pharmacological inhibition of key elements (DNA-PKcs and DNA ligase IV) of the canonical non-homologous end joining DNA repair pathway, thus providing the first evidence implicating this reparative cascade in the protection of the maternal genome.]]> Mon 23 Sep 2019 10:15:15 AEST ]]> Heat exposure induces oxidative stress and DNA damage in the male germ line https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47477 0.05). Collectively, our acute heat stress model supports the existence of heat susceptible stages of germ cell development, with the round spermatids being most perturbed and spermatogonial stem cells exhibiting resistance to this insult. Such findings were complemented by our chronic heat stress model, which further supported the vulnerability of the round spermatid population.]]> Mon 23 Jan 2023 11:33:24 AEDT ]]> Metabolic Changes Accompanying Spermatogonial Stem Cell Differentiation https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40758 Mon 18 Jul 2022 13:54:17 AEST ]]> Mass spectrometry reveals distinct proteomic profiles in high- And low-quality stallion spermatozoa https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40738 Mon 18 Jul 2022 13:12:16 AEST ]]> Evidence that extrapancreatic insulin production is involved in the mediation of sperm survival https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40400 Mon 11 Jul 2022 13:55:46 AEST ]]> Epididymal CYP2E1 plays a critical role in acrylamide-induced DNA damage in spermatozoa and paternally mediated embryonic resorptions https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34117 Mon 11 Feb 2019 16:05:21 AEDT ]]> Male infertility and somatic health — insights into lipid damage as a mechanistic link https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51402 Mon 04 Sep 2023 14:52:16 AEST ]]> GLIPR1L1 is an IZUMO-binding protein required for optimal fertilization in the mouse https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36447 Mon 04 May 2020 16:14:04 AEST ]]> High Resolution Proteomic Analysis of Subcellular Fractionated Boar Spermatozoa Provides Comprehensive Insights Into Perinuclear Theca-Residing Proteins https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48239 Mon 01 May 2023 14:49:55 AEST ]]> Acrylamide modulates the mouse epididymal proteome to drive alterations in the sperm small non-coding RNA profile and dysregulate embryo development https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40281 Fri 29 Jul 2022 13:23:12 AEST ]]> Assessment of the Emerging Threat Posed by Perfluoroalkyl and Polyfluoroalkyl Substances to Male Reproduction in Humans https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45427 Fri 28 Oct 2022 11:48:22 AEDT ]]> New horizons in human sperm selection for assisted reproduction https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51228 Fri 25 Aug 2023 11:51:38 AEST ]]> Differential cell death decisions in the testis: evidence for an exclusive window of ferroptosis in round spermatids https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36974 Fri 24 Jul 2020 14:55:41 AEST ]]> ONC201 in combination with paxalisib for the treatment of H3K27-altered diffuse midline glioma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53140 Fri 17 Nov 2023 11:42:18 AEDT ]]> Gross and microanatomy of the male reproductive duct system of the saltwater crocodile Crocodylus porosus https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49362 Fri 12 May 2023 12:35:13 AEST ]]> EPAS1 expression contributes to maintenance of the primordial follicle pool in the mouse ovary https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55287 Fri 10 May 2024 16:22:11 AEST ]]> Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51529 Fri 08 Sep 2023 12:10:33 AEST ]]> A model protocol for the cryopreservation and recovery of motile lizard sperm using the phosphodiesterase inhibitor caffeine https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38175 Fri 06 Aug 2021 14:14:50 AEST ]]>